Differential cyclophosphamide sensitivity of suppressor and cytotoxic cell precursors

Ferguson, R.M.; Simmons, R.L.

Transplantation 25(1): 36-38


ISSN/ISBN: 0041-1337
PMID: 619482
DOI: 10.1097/00007890-197801000-00009
Accession: 005153827

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There is considerable indirect evidence that cyclophosphamide (CY) exhibits a selective action on various populations and subpopulations of lymphoid cells when injected in vivo. Many of the effects of CY depend on its dose and timing with respect to antigen administration, but both immunodepressive and immunoenhancing effects have been repeatedly observed. The indirect demonstrations that T [thymus-derived] cell subpopulations display a differential sensitivity to CY prompted the present experiments, which were designed to test this hypothesis directly by assaying for in vitro suppression and cytotoxicity using spleen cells from mice treated with CY in vivo.