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Differential efficacy of mebendazole and albendazole against Necator americanus but not for Trichuris trichiura infestations



Differential efficacy of mebendazole and albendazole against Necator americanus but not for Trichuris trichiura infestations



European Journal of Clinical Pharmacology 32(6): 635-637



The effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, with T. trichiura and/or N. americanus infestation has been studied. Both albendazole and mebendazole cured more than 90% of T. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate for N. americanus infestations. Thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects with T. trichiura and/or N. americanus infestations.

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Accession: 005155655

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PMID: 3653234


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