EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Differential involvement of the lipoproteins in cholesterol transport depending on the level of plasma cholesterol study in hypercholesterolemic hamsters



Differential involvement of the lipoproteins in cholesterol transport depending on the level of plasma cholesterol study in hypercholesterolemic hamsters



Nutrition Research 6(9): 1075-1082



FEC hamsters were used to explore to what extent they could maintain an unchanged distribution of plasma cholesterol among the lipoproteins in becoming even more hypercholesterolemic when fed high-cholesterol diets (0.1% or 0.5). The results showed that the percentage of cholesterol was significantly changed only in the VLDL by cholesterol supplement in the diet. These lipoproteins became already maximally enriched with cholesterol in animals fed the diet with the lower percentage of cholesterol. More interesting were the alterations observed in the distribution of the excess exogenous cholesterol among the lipoproteins. Up to 200 mg/100 ml of total cholesterol in whole plasma, the cholesterol transported in the IDL and HDL fractions increased significantly. Above this concentration, the excess exogenous cholesterol was located only to the VLDL. There was a close relation between the VLDL cholesterol content and the level of cholesterol in whole plasma. Thus, the involvement of the lipoprotein in cholesterol transport depended on the level of plasma cholesterol which was itself related to the dietary cholesterol intake.

(PDF emailed within 0-6 h: $19.90)

Accession: 005156478

Download citation: RISBibTeXText

DOI: 10.1016/S0271-5317(86)80050-1



Related references

Cholesterol metabolism in the genetically hypercholesterolemic (RICO) rat. II. A study of plasma lipoproteins and effect of dietary cholesterol. Biochimica et Biophysica Acta 960(3): 382-389, 1988

Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor l-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. Journal of agricultural and food chemistry4 53(9): 3403-3407, 2005

Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha -isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. Journal of Agricultural and Food Chemistry 53(9): 3403-3407, 2005

Different palm oil preparations reduce plasma cholesterol concentrations and aortic cholesterol accumulation compared to coconut oil in hypercholesterolemic hamsters. Journal of Nutritional Biochemistry 16(10): 633-640, 2005

Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. Journal of Nutritional Biochemistry 18(2): 105-112, 2006

Guar gum and plasma cholesterol. Effect of guar gum and an oat fiber source on plasma lipoproteins and cholesterol in hypercholesterolemic adults. Arteriosclerosis and Thrombosis 11(5): 1204-1208, 1991

Hamsters fed diets high in saturated fat have increased cholesterol accumulation and cytokine production in the aortic arch compared with cholesterol-fed hamsters with moderately elevated plasma non-HDL cholesterol concentrations. Journal of Nutrition 134(2): 410-415, 2004

Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. Journal of Nutrition 123(10): 1693-1702, 1993

Cholesterol transport between cells and body fluids. Role of plasma lipoproteins and the plasma cholesterol esterification system. Medical Clinics of North America 66(2): 363-373, 1982

Reduction of cholesterol transported in apo B-rich lipoproteins in spontaneously hypercholesterolemic hamsters fed an apple-supplemented diet. Annals of Nutrition & Metabolism 31(1): 1-8, 1987

Effect of plasma lipoproteins on cholesterol accumulation in macrophages comparison of lipoproteins from normal and homozygous familial hypercholesterolemic subjects. Atherosclerosis 65(3): 207-214, 1987

Cholesterol absorption and transport in thoracic duct lymph lipoproteins of nonhuman primates. Effect of dietary cholesterol level. Journal of Lipid Research 24(4): 343-356, 1983

Reduction of plasma cholesterol by phloracetophenone in hypercholesterolemic hamsters. FASEB Journal 14(4): A429, March 15, 2000

Plasma cholesterol esterification and lipoprotein profile in hypercholesterolemic hamsters. Nutrition Research 8(2): 219-224, 1988

Dietary cholesterol affects plasma lipid levels, the intravascular processing of lipoproteins and reverse cholesterol transport without increasing the risk for heart disease. Nutrients 4(8): 1015-1025, 2013