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Differential recognition of the serologically defined hla a 2 antigen by allogeneic cyto toxic t cells 2. definition of 3 hla a 2 subtypes by cyto toxic t lymphocytes



Differential recognition of the serologically defined hla a 2 antigen by allogeneic cyto toxic t cells 2. definition of 3 hla a 2 subtypes by cyto toxic t lymphocytes



Immunogenetics 17(6): 599-608



A comprehensive analysis of human alloimmune cytotoxic T lymphocytes (CTL) specific for the HLA-A2 antigen identified 11% of HLA-A2-positive cells as outliers; 11 unrelated, serologically indistinguishable, but distinguishable by cell-mediated lympholysis (CML), HLA-A2 positive outlier cells were identified. The outlier cells could be subdivided into 2 subgroups according to reactivity patterns obtained with CTL directed against the HLA-A2 antigen of outlier cells and their inhibitory capacity in specific competitive inhibition experiments. Thus, the serologically defined HLA-A2 specificity can be divided into at least 3 subtypes using CTL specific for the HLA-A2 antigen. CTL specific for an HLA-A2 subtype were induced when responder cells expressed a different HLA-A2 subtype antigen. On the basis of several family studies, it is concluded that the subtype HLA-A2 antigens are inherited in a codominant way.

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Accession: 005157206

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