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Differential suppression of fsh and luteinizing hormone secretion in vivo by a gonadotropin releasing hormone antagonist



Differential suppression of fsh and luteinizing hormone secretion in vivo by a gonadotropin releasing hormone antagonist



Neuroendocrinology 40(3): 246-252



Because of some indication that FSH secretion is less dependent than LH [luteinizing hormone] secretion on GnRH in vivo, experiments were performed to examine the effects of a GnRH [gonadotropin-releasing hormone] antagonist (antag) on LH and FSH secretion. Pituitary cells [rat] superfused with GnRH showed a similar pattern of suppressed secretion of both LH and FSH in response to addition of antag. Antag administration to ovariectomized rats had differing effects on LH and FSH secretion. Serum LH was suppressed in a dose-dependent fashion by 2 h (20-50% of control values). Recovery from the lower doses of antag was seen by 12 h, but the 2 highest doses maintained serum LH levels at 10% of control values for 72 h. The effect on serum FSH was not manifested until 12 h. FSH was maximally decreased only to 40-60% of control values. The 2 highest doses maintained this effect for 72 h. Evidently, FSH secretion in vivo may occur independently of acute changes in GnRH secretion, and may have an GnRH-independent component.

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Accession: 005158144

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