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Differentiation of chronic lymphocytic leukemia from Hodgkin's disease using immunologic marker studies

Differentiation of chronic lymphocytic leukemia from Hodgkin's disease using immunologic marker studies

American Journal of Surgical Pathology 5(7): 707-710

Four consecutive lymph node biopsies from one patient showed features typical of lymphocyte-pre-dominant Hodgkin's disease. When the patient developed lymphocytosis of the peripheral blood and a staging bone marrow biopsy was found to have nodular lymphoid infiltrates atypical for Hodgkin's disease, the fourth node biopsy was performed in order to perform immunologic marker studies. A monoclonal cell population was identified and the lymph nodes were interpreted as chronic lymphocytic leukemia mimicking lymphocyte-predominant Hodgkin's disease. The diagnostic usefulness of immunologic marker studies stressed.

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Accession: 005159202

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PMID: 7039376

DOI: 10.1097/00000478-198110000-00014

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