EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Diffusional delay in local anesthetic block in vitro


Anesthesiology 61(5): 555-557
Diffusional delay in local anesthetic block in vitro
The diffusion of lidocaine to myelinated and unmyelinated axons was compared on individual afferent fibers of rabbit vagus nerve. The criterion consisted of the time required for more than 95% completion of the asymptotic increase in impulse conduction time produced by a weak, nonblocking concentration of lidocaine. Measurements on sheathed and desheathed nerves for both myelinated and unmyelinated axons detected an apparent but statistically not significant diffusional lag at the perineurial sheath, averaging four minutes in this model; there was no significant difference in the mean time for attainment of criterion in myelinated and unmyelinated axons, which averaged an additional 13 min in both types of fiber. From these observations the authors conclude that lidocaine diffused as readily through the nodal gap to the excitable membrane of the myelinated fiber as through the Schwann cell mesaxon to the unmyelinated fiber. Thus differential diffusion within a nerve seems unlikely to be a contributing factor to clinical differential block.


Accession: 005161100

PMID: 6496993

DOI: 10.1097/00000542-198411000-00014



Related references

Local anesthetic systemic toxicity after combined psoas compartment-sciatic nerve block: analysis of decision factors and diagnostic delay. Anesthesiology 120(4): 987-996, 2014

Editorial comment: cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon and probable local anesthetic systemic toxicity in a postpartum patient with acute Fatty liver of pregnancy after a transversus abdominis plane block. A & A Case Reports 1(5): 77-78, 2015

Effect of local anesthetic concentration on the anesthetic level in digital transthecal block. Journal of the Formosan Medical Association 104(9): 684-686, 2005

Comparative anesthetic properties of various local anesthetic agents in extradural block for labor. British Journal of Anaesthesia 49(1): 75-79, 1977

Epidural block using large volumes of local anesthetic solution for intercostal nerve block. Anesthesiology 63(2): 214-216, 1985

The impact of local anesthetic distribution on block onset in ultrasound-guided interscalene block. Acta Anaesthesiologica Scandinavica 56(9): 1146-1151, 2013

Phrenic nerve block caused by interscalene brachial plexus block: Effects of digital pressure and a low volume of local anesthetic. Regional Anesthesia & Pain Medicine 24(3): 231-235, May-June, 1999

Phrenic nerve block caused by interscalene brachial plexus block: effects of digital pressure and a low volume of local anesthetic. Regional Anesthesia and Pain Medicine 24(3): 231-235, 1999

Cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon. A & A Case Reports 1(5): 75-76, 2015

Alkalinization of local anesthetics. Which block, which local anesthetic?. Regional Anesthesia 20(5): 369-377, 1995