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Diflunisal a new analgesic in the treatment of post operative pain following removal of impacted mandibular 3rd molars



Diflunisal a new analgesic in the treatment of post operative pain following removal of impacted mandibular 3rd molars



International Journal of Oral Surgery 8(2): 102-113



Diflunisal, 5-(2', 4'-difluorophenyl) -salicylic acid, has been shown in animal and human studies to possess pronounced analgesic and anti-inflammatory effects. The analgesic effect and safety of 3 doses of 500 mg diflunisal, given orally over 36 h, was compared with placebo in the treatment of pain following surgical removal of impacted mandibular 3rd molars. A total of 60 patients, 30 patients in each treatment group, participated in this double-blind, completely randomized study. The treatment groups were compared for demographic data, disease-related variables and pretreatment severity of pain. According to both the investigator's and the patient's overall evaluation of treatment efficacy on postoperative pain, diflunisal was significantly better than placebo (P < 0.0001). Clinical adverse reactions were reported by 7 patients (25%) in the diflunisal group compared to 3 patients (11%) in the control group. In 2 instances the adverse reactions were rated by the investigator to have been unacceptable. Diflunisal, compared to placebo, is evidently a highly effective and well-tolerated analgesic in the treatment of postoperative pain following surgical removal of impacted mandibular 3rd molars.

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Accession: 005161170

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