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Diflunisal. A new oral analgesic with an unusually long duration of action

JAMA 248(17): 2139-2142

Diflunisal. A new oral analgesic with an unusually long duration of action

The analgesic efficacy of single 500- and 1,000-mg doses of diflunisal (Dolobid), a new nonsteroidal anti-inflammatory analgesic, was compared in a double-blind study with that of acetaminophen, 600 mg, the combination of acetaminophen, 600 mg, with codeine phosphate, 60 mg, and placebo in 159 oral surgery outpatients. Using a self-rating record, patients rated their pain and its relief hourly for 12 hours after medication. Both doses of diflunisal were significantly more effective than acetaminophen alone and produced peak analgesia comparable to that of the acetaminophen-codeine combination. Diflunisal proved to have an unusually long duration of analgesic action. Acetaminophen and the combination were significantly superior to placebo through hours 2 and 5, respectively; both doses of diflunisal were significantly superior through the end of the 12-hour observation period. None of the active treatments produced more side effects than the placebo.

Accession: 005161171

PMID: 6750171

Related references

Kinnunen J.; Pernu H., 1987: Analgesic efficacy and tolerability of diflunisal in oral surgery. A double-blind, completely randomized study was carried out on 169 patients to compare the analgesic efficacy and tolerability of diflunisal with that of Veralgin after surgical removal of impacted third molars. One group received 1000 mg diflunis...

Bahous I.; Lutterbeck P.M.; Tempero K.F., 1978: Diflunisal a novel long acting analgesic. Clinical Therapeutics 1(SUPPL A): 10-19

Bella, G.; Russo, S.; Messina, G., 1987: Clinical trial of a new non-steroidal analgesic (diflunisal) in oral surgery. Minerva Stomatologica 36(4): 297-300

Walker J.S.; Levy G., 1990: Effect of multiple dosing on the analgesic action of diflunisal in rats. This investigation was designed to compare the analgesic effect of the initial dose of a repetitively dosed non-narcotic analgesic with the analgesic effect of a subsequent dose given 3 days later. To exclude gradual drug accumulation as a variabl...

Holguin J.A., 1988: Ionophoretic and inhibitory action of the analgesic diflunisal on sarcoplasmic reticulum. Diflunisal decreased the ATP-dependent transport rate and calcium accumulation by the sacropolasmic reticulum. Inhibition of calcium transport by diflunisal was pH dependent, and a pKa of 6.7 to 6.9 was observed for the carboxylic acid group. In s...

Beaver, W.T.; Forbes, J.A.; Shackleford, R.W., 1983: A method for the 12-hour evaluation of analgesic efficacy in outpatients with postoperative oral surgery pain. Three studies of diflunisal. We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration of outpatients with postoperative oral surgery pain. Using a self-rating record, patients evaluate their pain and its relief f...

Forbes, J.A.; Butterworth, G.A.; Burchfield, W.H.; Beaver, W.T.; Shackleford, R.W., 1983: A 12-hour evaluation of the analgesic efficacy of diflunisal, zomepirac sodium, aspirin, and placebo in postoperative oral surgery pain. One hundred ninety-nine outpatients with pain following oral surgery were randomly assigned, on a double-blind basis, a single oral dose of diflunisal (500 or 1,000 mg), zomepirac sodium 100 mg, aspirin 650 mg, or placebo. Using a self-rating reco...

Rodrigo M.R.C.; Rosenquist J.B., 1990: Does midazolam sedation in oral surgery affect the potency or duration of diflunisal analgesia. A randomized cross-over study was carried out to determine whether midazolam in doses used for conscious sedation had any effect on the potency or duration of diflunisal, a non-narcotic analgesic used for postoperative pain in oral surgery. Thirty...

Aoki, T.; Ota, Y.; Mori, Y.; Otsuru, M.; Ota, M.; Kaneko, A., 2016: Analgesic efficacy of celecoxib in patients after oral surgery: special reference to time to onset of analgesia and duration of analgesic effect. Cyclooxygenase-2 inhibitor celecoxib is also used in the dental field for analgesia. However, there are few reports on the time to onset and duration of analgesia. We investigated the analgesic effect of celecoxib after oral surgery. A total of 13...

Fonseca, J.B.; Gregori, C.; de Moura Campos, F.E.; Piratininga, J.L.; da Gra├ža Naclerio Homem, M.; de Souza Lobo, N.B.; Antonini, R., 1980: Analgesic and anti-inflammatory action of Diflunisal in dental surgery. Comparative clinical study in combination with Trypsin/chymotrypsin/P-amino-phenol. Ars Curandi Em Odontologia 7(7): 313-322