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Digital imaging studies of aluminum and calcium in neurofibrillary tangle bearing neurons using secondary ion mass spectrometry

, : Digital imaging studies of aluminum and calcium in neurofibrillary tangle bearing neurons using secondary ion mass spectrometry. Trace Elements in Medicine 4(3): 99-104

Digital imaging techniques are used in concert with high spatial resolution secondary ion mass spectrometry (SIMS) to study the distribution of potentially toxic metals in brain tissue. In agreement with prior electron microprobe experiments, both Al and Ca are found to be associated with neurofibrillary tangle (NFT)-bearing neurons in the hippocampus of patients with parkinsonism dementia. Studies include high mass resolution spectra (Al, Si) and secondary ion images (Al, Ca, P) of NFT-bearing neurons. The high mass resolution results confirm the absence of mass spectral interferences (26Mg1H+, 12C21H+) with 27Al+. Line scans and ion images indicate Al and Ca localization to NFT-bearing neurons, with highest apparent concentrations in the neuronal nuclei.

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