Discriminative action of hydrazine sulfate in combination with thio phosphamide on tumor cell mitochondria
Tret'yakov A.V.; Golovatova, V.A.; Filov, V.A.
Voprosy Onkologii (St Petersburg) 28(3): 86-88
ISSN/ISBN: 0507-3758 Accession: 005168751
Hydrazine sulfate significantly potentiated the antitumor effect of thiophosphamide in experiments on rats with Walker's tumor. The treatment with hydrazine sulfate (60 mg/kg) plus thiophosphamide (1 mg/kg) resulted in suppression of tumor growth of up to 90%, the dosage of thiophosphamide being therapeutically ineffective. Following hydrazine sulfate treatment, the activity of ATPase (pH: 7.0-7.5-7.75) derived from tumors doubled as compared with control. Similar results were obtained with enzymatic preparations. The activities of DNP[2,4-dinitrophenol]-stimulated ATPase and solubilized enzymes in rat liver were not influenced by treatment.