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Discriminative action of hydrazine sulfate in combination with thio phosphamide on tumor cell mitochondria

Tret'yakov A.V.; Golovatova, V.A.; Filov, V.A.

Voprosy Onkologii (St Petersburg) 28(3): 86-88

1982

ISSN/ISBN: 0507-3758
Accession: 005168751
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Hydrazine sulfate significantly potentiated the antitumor effect of thiophosphamide in experiments on rats with Walker's tumor. The treatment with hydrazine sulfate (60 mg/kg) plus thiophosphamide (1 mg/kg) resulted in suppression of tumor growth of up to 90%, the dosage of thiophosphamide being therapeutically ineffective. Following hydrazine sulfate treatment, the activity of ATPase (pH: 7.0-7.5-7.75) derived from tumors doubled as compared with control. Similar results were obtained with enzymatic preparations. The activities of DNP[2,4-dinitrophenol]-stimulated ATPase and solubilized enzymes in rat liver were not influenced by treatment.

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Related References

Tret'yakov A.; Golovatova, V.A.; Filov, V.A. 1983: Selective action of hydrazine sulfate combined with thio phosphamide on tumor cell mitochondria Journal of Soviet Oncology 4(4): 358-359
Tret'iakov, A.V.; Golovatova, V.A.; Filov, V.A. 1982: Selective action of hydrazine sulfate in combination with thiophosphamide on tumor cell mitochondria Voprosy Onkologii 28(3): 86-88
Bulovskaya, L.N.; Kolosov, A.I. 1976: Acetylation in mice during the use of thio phosphamide and hydrazine sulfate Voprosy Onkologii (Stsburg). 22(6): 94-95
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Valavichyus, Y.M.; Valavichene, Y.V. 1982: Effect of adrenaline on fluoro uracil thio phosphamide and cyclo phosphamide toxicity and on the survival rate of intact and tumor bearing rats Lietuvos TSR Mokslu Akademijos Darbai Serija C Biologijos Mokslai 4: 109-113
Gold, J. 1988: Combination effect of vp 16 vitamin k3 menadione and hydrazine sulfate in tumor bearing animals Proceedings of the American Association for Cancer Research Annual Meeting 29: 326
Tret'yakov A.V.; Filov, V.A.; Ryazanov, E.M.; Tarkov, A.S. 1979: Experimental data indicating hydrazine sulfate anti tumor action Voprosy Onkologii (St Petersburg) 25(6): 100-103
Filov, V.A.; Stukov, A.N.; Blank, M.A.; Neĭshtadt, E.L. 1978: Experimental data on the toxic action of hydrazine sulfate on the body and on a tumor Farmakologiia i Toksikologiia 41(2): 203-205
Tret'yakov A.V.; Filov, V.A.; Ryazanov, E.M.; Tarkov, A.S. 1980: Experimental data substantiating anti tumor action of hydrazine sulfate Journal of Soviet Oncology 1(2): 139-142
Filov, V.A.; Stukov, A.N.; Blank, M.A.; Neishtadt, E.L. 1978: Experimental data on toxic action of hydrazine sulfate on the body and tumor Farmakologiya i Toksikologiya 41(2): 203-205