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Displacement of tritiated ethylketocyclazocine binding by opioids in rat kidney a correlate to diuretic activity

Displacement of tritiated ethylketocyclazocine binding by opioids in rat kidney a correlate to diuretic activity

Life Sciences 36(23): 2189-2194

Multiple opioid binding sites were documented in brain tissue. The presence of binding sites for the opioid ethylketocyclazocine (EKC) in a membrane fraction of rat kidney is reported. Binding appeared to be selective in that opioids varied markedly in their capacities to displace 3H-EKC. Correlating with the capacity of an opioid to displace 3H-EKC was the ability to produce diuresis. Although these studies cannot assign a particular physiological or pharmacological role for the renal EKC binding sites, binding studies of this nature may, nonetheless, be a means by which diuretic activity of opioids can be predicted.

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Accession: 005170448

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