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Disposition kinetics of 2 oral forms of quinidine






Clinical Pharmacology and Therapeutics 19((5 PART 1)): 566-575

Disposition kinetics of 2 oral forms of quinidine

Conventional quinidine sulfate [an antiarrhythmic agent] and a slow-release quinidine bisulfate were studied in 10 normal subjects. Single and repetitive doses were given; blood and urine concentrations were measured by the method of Cramer and Isaakson. After a single dose of 2 tablets of quinidine sulfate (400 mg), the average peak concentration was 2.13 .+-. 0.22 .mu.g/mg (.+-. SE of the mean); following 2 tablets of the slow-release form, the average peak concentration was 1.17 .+-. 0.12 .mu.g/ml. T-max was approximately 2 h with quinidine sulfate and 4 h with quinidine bisulfate. One-fourth of both forms of the drug was recovered in the urine. Total body clearance was 0.36 l/kg h and renal clearance was 117 .+-. 22 ml/min for both. With multiple dosing the serum quinidine concentration was higher than these predicted from the results of the single dose study. Based on the mean estimates of quinidine half-life of 6 h, a rapid method for achieving steady-state levels of quinidine would be to give an initial dose twice that of the maintenance dose. With the slow-release product if an equivalent dose was given every 12 h, the mean steady-state quinidine serum concentration would be approximately the same.

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Accession: 005170673



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