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Disposition of pulse dose methyl prednisolone in adult and pediatric patients with the nephrotic syndrome

European Journal of Clinical Pharmacology 23(5): 429-434

Disposition of pulse dose methyl prednisolone in adult and pediatric patients with the nephrotic syndrome

The disposition of a large pulse-dose of methylprednisolone was examined in pediatric and adult patients with the nephrotic syndrome. Plasma concentrations and urinary excretion rates were measured by high-performance liquid chromatography. Most of the dose was metabolized, as indicated by urinary recovery of < 10% of the dose. There was only slight age-dependence of the plasma clearance and volume of distribution of the steroid, although the t1/2 [half-life] and mean transit time were shorter in younger patients. The pharmacokinetic parameters of the large doses (12-20 mg/kg) were similar to low dose (0.5-1 mg/kg) data from asthmatic patients. The limited variability of the pharmacokinetics of methylprednisolone suggests that tissue sensitivity may be a more important indicator of drug dosage needs in nephrotic syndrome.

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Accession: 005170955

PMID: 7151847

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