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Distribution and hemodynamics of radioactive carbon from uniformly labeled carbon 14 glucose by the cerebral administration in mice rats and dogs studies on macro auto radiograms



Distribution and hemodynamics of radioactive carbon from uniformly labeled carbon 14 glucose by the cerebral administration in mice rats and dogs studies on macro auto radiograms



Nichidai Igaku Zasshi 35(10): 1065-1075



Macroautoradiographic distribution of [U][uniformly-labeled]-14C-glucose was examined in mice, rats and dogs. In mice and rats the drug was administered intracerebrally according to the method of Haley and McCormick, and whole body autoradiograms were prepared. The drug was administered into the lateral ventricle of the dogs according to the method of Feldberg, and partial cerebral autoradiograms were prepared with the technique of Sato. Autoradiograms after systemic administration (from the tail vein) were prepared for controls. A photopattern analyzer detected radioactivity of 14C in glucose on the films. Ratios of density (RD) in the brain, spinal cord, liver, kidney, heart, lung, urinary bladder and intestine were measured using the analyzer in mice injected both intracerebrally and i.v. Similar findings in autoradiograms were observed between mice and rats. A significant difference was observed between the fate of 14C-glucose after peripheral and central injections. The time course of RD in the CNS (i.e., the brain and spinal cord) and liver, which had a little difference from the former, showed chevron-form; in the other organs, convex form occurred. When the drug was injected intracerebrally the RD was gradually decreased after the injection in the brain, heart and kidney; those in the lung, liver and intestine showed chevron-form. In dog brain the RD showed a peak 10 min after the injection of the drug.

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