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Distribution of measles antigen and immuno globulin containing cells in the central nervous system in subacute sclerosing pan encephalitis and atypical measles encephalitis



Distribution of measles antigen and immuno globulin containing cells in the central nervous system in subacute sclerosing pan encephalitis and atypical measles encephalitis



Journal of the Neurological Sciences 53(1): 29-44



The immunoperoxidase technique was used to study the distribution of measles virus antigen and Ig-containing cells within the CNS, in 5 cases of subacute sclerosing panencephalitis (SSPE) and 1 case of atypical measles encephalitis. Measles virus antigen was demonstrated within the brain in all cases, and in the spinal cord in 1 case of SSPE. Ig-containing cells were also demonstrated in all cases, the proportions of the different L and H chain types varying somewhat from case to case. In SSPE IgG constituted the major and IgA the principal minor H chain demonstrated. In all cases of SSPE there was significant excess of L chain-containing over H chain-containing cells. In the case of atypical measles encephalitis there was a paucity of Ig-containing cells and a relatively high proportion (39%) of these contained IgM. The case of atypical measles encephalitis differed from those of SSPE also in the presence of multinucleate giant cells, some of which contained measles virus antigen.

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Accession: 005179021

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Distribution of measles antigen and immunoglobulin-containing cells in the CNS in subacute sclerosing panencephalitis (SSPE) and atypical measles encephalitis. Journal of the Neurological Sciences 53(1): 29-43, 1982

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