Section 6
Chapter 5,189

Does basic aluminum sucrose sulfate affect blood coagulability?

Mcgraw, B.F.; Hesterlee, E.J.; Gitomer, S.L.; Hollander, D.H.

Research Communications in Chemical Pathology and Pharmacology 30(2): 373-376


ISSN/ISBN: 0034-5164
PMID: 6893754
Accession: 005188749

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Basic aluminum sucrose sulfate (sucralfate) is a sulfated disaccharide similar in structure to heparin that has been shown not to possess anticoagulant effects in vitro or in animal models. As an adjunct to a study of the efficacy of sucralfate in the treatment of duodenal ulcer disease, we evaluated the drug's anticoagulant effects. Twenty-eight patients were randimized to treatment with sucralfate. Evaluations of prothrombin time and activated partial thromboplastin time, prestudy and after two and/or four weeks of treatment with sucralfate, demonstrated no evidence of anticoagulant activity.

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