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Dose response sex difference and the effect of bran in di methyl hydrazine induced intestinal tumorigenesis in rats



Dose response sex difference and the effect of bran in di methyl hydrazine induced intestinal tumorigenesis in rats



Toxicology & Applied Pharmacology 55(3): 417-422



Dose-response and sex difference were examined in rats to the experimental colonic carcinogen dimethylhydrazine (DMH). Ten male and ten female weanling Sprague-Dawley rats were used in each group: Group 1.sbd.control, Group II.sbd.20% bran in the diet, Group III.sbd.15 mg/kg DMH given as 10 weekly oral doses, Group IV.sbd.bran and 15 mg/kg DMH, Group V.sbd.30 mg/kg DMH given as 10 weekly oral doses and Group VI.sbd.bran and 30 mg/kg DMH. Male rats in Groups III and V had 2.1 and 6.4 colonic tumors/rat, respectively, and at the high dose of DMH, there was a 100% incidence of rats with colonic tumors. The addition of bran to the diet reduced the formation of colonic tumors. Female rats in Groups III and V had 0.2 and 0.6 colonic tumors/rat, respectively, but only a 30% incidence of colonic tumors at the high dose. Dietary bran had no effect on the production of intestinal tumors in females. In this model system, the effects of a dose-response and sex difference are important considerations in experimental design.

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Accession: 005193158

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PMID: 6254207



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