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Doxorubicin bleomycin vinblastine and dacarbazine salvage of mechlorethamine vincristine prednisone and procarbazine resistant advanced hodgkins disease



Doxorubicin bleomycin vinblastine and dacarbazine salvage of mechlorethamine vincristine prednisone and procarbazine resistant advanced hodgkins disease



Cancer Treatment Reports 68(7-8): 947-952



Patients (39) with advanced Hodgkin's disease were treated with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). Of these patients, 31 had previously failed to respond to MOPP (mechlorethamine, vincristine, prednisone, procarbazine) treatment (29 patients) or to CCVPP (lomustine, cyclophosphamide, vincristine, procarbazine, prednisone) treatment (2 patients). Twenty-seven patients were considered evaluable. Eight (30%) patients achieved complete remission (CR), 2 (7%) achieved partial remission (PR) and 17 (63%) had no response. All of the complete responders are still in continuous unmaintained CR; 14 of the 19 partial responders and nonresponders have died. The overall median survival was 21 mo.; it was 16 mo. for partial responders and nonresponders. The remaining 8 patients had ABVD substituted for MOPP early in treatment, because of allergy to procarbazine; 6 patients achieved CR and 2 achieved PR. These results are in keeping with the literature data and confirm the effectiveness of ABVD as primary and salvage treatment in advanced Hodgkin's disease.

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Accession: 005195044

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