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Early lesions during pancreatic carcinogenesis induced in syrian hamster by di hydroxydi n propyl nitrosamine or di oxo di n propyl nitrosamine 1. histologic histochemical and radioautographic findings



Early lesions during pancreatic carcinogenesis induced in syrian hamster by di hydroxydi n propyl nitrosamine or di oxo di n propyl nitrosamine 1. histologic histochemical and radioautographic findings



Carcinogenesis 4(4): 431-438



The early lesions which arise in the Syrian hamster pancreas prior to the appearance of carcinomas induced by treatment with the related carcinogens, dihydroxydi-n-propylnitrosamine or dioxodi-n-propylnitrosamine, were investigated in order to assess their roles in tumorigenesis. A sequence of events is proposed leading from ductal or ductular proliferations through regions of epithelial atypia (so-called dysplastic lesions) to carcinomas. This sequence appears distinct from that leading from ductular proliferations to benign multilocular cysts or cystadenomas. Radioautographic and histochemical evidence is presented supporting this proposal linking atypical proliferations but not cystic lesions with the induced carcinomas. Increase in the activity of glucose-6-phosphate dehydrogenase was established as being a good histochemical marker for early atypical proliferations during pancreatic carcinogenesis, whereas .gamma.-glutamyl transpeptidase was found lacking in this respect. Alteration in polysaccharide metabolism was observed during the development of the carcinomas.

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