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Early vs. late onset psychosis and tardive dyskinesia

Early vs. late onset psychosis and tardive dyskinesia

Biological Psychiatry 21(13): 1291-1297

Patients with late-onset psychosis (defined as psychosis requiring hospitalization at age 45 or more, n = 20) were compared with early-onset psychosis patients (defined as psychosis requiring hospitalization at age 25 or less, n = 56) for the prevalence of tardive dyskinesia (TD). Late-onset psychosis patients were found to have significantly more TD (p < 0.01), which was more severe (p < 0.05) and developed in a relatively shorter period of neuroleptic treatment (p < 0.001), than patients with early-onset psychosis. In addition, TD patients (irrespective of early or late onset of neuroleptic treatment) were found to show a preponderance of drug-free periods (p < 0.01) in their past neuroleptic history, more so than non-TD patients. Our findings indicate that late-onset psychosis should be considered to be a risk factor for the development of TD.

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Accession: 005207310

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