Effect of a beta 2 sympathomimetic on penta gastrin stimulated and histamine stimulated gastric acid secretion in vagotomized gastric fistula dogs

Gottrup, F.; Ornsholt, J.; Andersen, D.

Scandinavian Journal of Gastroenterology 15(4): 561-568

1980


ISSN/ISBN: 0036-5521
Accession: 005215164

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Abstract
The effect of a .beta.2-adrenoceptor agonist on pentagastrin- and histamine-stimulated gastric acid secretion was studied in conscious vagotomized gastric fistula dogs. A dose-dependent inhibition was found after pentagastrin stimulation, but minor differences were found after histamine stimulation. No major differences between truncal, selective and parietal cell vagotomy were found after pentagastrin stimulation, but 1 truncal vagotomy dog showed a high inhibition after histamine stimulation. Dose-response experiments with 5 doses of pentagastrin or histamine (single-dose studies) and 2 doses of .beta.2-agonist suggested a change after vagotomy in the mechanisms of inhibition of gastric acid secretion: for pentagastrin, from a noncompetitive type to an uncompetitive type, and for histamine, from a competitive type to a nonsignificant inhibition. The dose-response curves for the vagotomized dogs were very similar to the curve from intact innervated dogs inhibited by a .beta.2-agonist, from an earlier study. A decrease in cholinergic tone and an increase in sympathetic tone may have identical effects on pentagastrin- and histamine-stimulated gastric acid secretion and a counterbalance between the 2 nervous systems on gastric acid secretion is suggested.