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Effect of a single breath of 100 percent oxygen on respiration in neonates during sleep



Effect of a single breath of 100 percent oxygen on respiration in neonates during sleep



Journal of Applied Physiology Respiratory Environmental & Exercise Physiology 57(5): 1531-1535



To determine the effect of a single breath of 100% O2 on ventilation, 10 full-term [body wt 3,360 .+-. 110 (SE) g, gestational age 39 .+-. 0.4 wk, postnatal age 3 .+-. 0.6 days] and 10 preterm neonates (body wt 2,020 .+-. 60 g, gestational age 34 .+-. 2 wk, postnatal age 9 .+-. 2 days) were studied during active and quiet sleep states. The single-breath method was used to measure peripheral chemoreceptor response. To enhance response and standardize the control period for all infants, fractional inspired O2 concentration was adjusted to 16 .+-. 0.6% for a control O2 saturation of 83 .+-. 1%. After 1 min of control in each sleep state, each infant was given a single breath of O2 followed by 21% O2. Minute ventilation (.ovrhdot.VE), tidal volume (VT), breathing frequency (f), alveolar O2 and CO2 tension, O2 saturation (ear oximeter), and transcutaneous O2 tension, O2 saturation (ear oximeter), and transcutaneous O2 tension were measured. .ovrhdot.VE always decreased with inhalation of O2 (P < 0.01). In quiet sleep, the decrease in .ovrhdot.VE was less in full-term (14%) than in preterm (40%) infants (P < 0.001). Decrease in .ovrhdot.VE was due primarily to a drop in VT in full-term infants as opposed to a fall in f and VT in preterm infants (P < 0.05). Apnea, as part of the response, was more prevalent in preterm than in full-term infants. In active sleep the decrease in .ovrhdot.VE was similar both among full-term (19%) and preterm (21%) infants (P > 0.5). These results suggest greater peripheral chemoreceptor response in preterm than in full-term infants, reflected by a more pronounced decrease in .ovrhdot.VE with O2. The results are compatible with a more powerful peripheral chemoreceptor contribution to breathing in preterm than in full-term infants.

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Accession: 005215937

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Effect of a single breath of 100% oxygen on respiration in neonates during sleep. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 57(5): 1531-1535, 1984

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