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Effect of acetaldehyde on whole body protein synthesis in rats


Nutrition Reports International 31(3): 661-668
Effect of acetaldehyde on whole body protein synthesis in rats
The effect of [the ethanol metabolite] acetaldehyde (10 mgd-1 100 g-1 body-weight for 27 days) on whole-body protein synthesis in rats was studied. No significant differences in food intake or growth rate of the rats were observed during this period. Whole-body protein synthesis, measured by [14C]-tyrosine constant infusion, was not significantly different between acetaldehyde-treated and control rats. Tyrosine oxidation was decreased by acetaldehyde but this decrease was highly variable between individual rats, such that the difference between test and control groups of rats was not significant. These data are discussed in relation to the inhibition by acetaldehyde of tissue protein synthesis in vitro observed by others.


Accession: 005216399



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