Effect of adjuvant induced arthritis on central and adrenal biogenic amines dopamine noradrenaline adrenaline 5 hydroxy tryptamine induced in lewis rats

Tissot, M.; Beauvallet, M.; Giroud, J.P.

Journal de Pharmacologie 9(3): 193-204


ISSN/ISBN: 0021-793X
Accession: 005217521

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The levels of biogenic amines in the brain (noradrenaline ) were measured at intervals during th 28-day course of inflammatory reactions induced in inbred Lewis rats by injection of either incomplete Freunds adjuvant (ICFA) or complete Freunds adjuvant (CFA). Rats treated with ICFA showed no variation in either brain or adrenal amine levels during the course of the inflammatory reaction. In CFA-treated rats there was likewise no change in the brain levels of dopamine and 5-hydroxytryptamine. The brain levels of noradrenaline was significantly increased on the 21st day after injection while the level of adrenaline in the adrenal medulla was significantly increased on both the 21st and 28th days after injection. These rises were accompanied by an increase in the urinary excretion of these 2 amines.