Effect of adrenaline on fluoro uracil thio phosphamide and cyclo phosphamide toxicity and on the survival rate of intact and tumor bearing rats
Valavichyus, Y.M.; Valavichene, Y.V.
Lietuvos TSR Mokslu Akademijos Darbai Serija C Biologijos Mokslai 4: 109-113
1982
Accession: 005217678
Adrenaline [epinephrine] (100 .mu.g/kg for 10 days or 60 .mu.g/kg for 20 days) combined with fluorouracil (50 mg/kg for 5 days, thiophosphamide (4 mg/kg for 7 days or 30 mg/kg for 15 days), or cyclophosphamide (40 mg/kg for 5 days) increased rat body weight, spleen weight, the length of 100% survival and mean longevity, compared to rats to which only cytostatics were administered. Five-fold administration of fluorouracil combined with epinephrine for 10 days to rats with transplanted sarcoma 45 increased rat 100% survival and mean longevity and completely retained the antitumor effect of the preparation. Five-fold administration of thiophosphamide combined with epinephrine for 10 days to rats with transplanted sarcoma 45 did not increase the antitumor activity of thiophosphamide, but increased rat 100% survival and mean longevity. Five-fold administration of cyclophosphamide combined with epinephrine for 10 days to rats with transplanted sarcoma 45 increased rat 100% survival and mean longevity and also contributed to a significant delay in tumor growth, compared to administration of only cyclophosphamide.