Effect of adrenergic receptor blockade on cortisol and growth hormone response to insulin induced hypo glycemia in man

Jezova Repcekova, D.; Klimes, I.; Jurcovicova, J.; Vigas, M.

International Journal of Clinical Pharmacology and Biopharmacy 17(2): 64-67


ISSN/ISBN: 0946-1965
Accession: 005217740

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The effect of several drugs presumably influencing central catecholaminergic receptors on plasma cortisol and GH response to insulin-induced hypoglycemia was studied in healthy adult males. The i.v. infusion of .alpha.-adrenergic blocking agents tolazoline or phentolamine suppressed plasma cortisol and GH response to insulin-induced hypoglycemia. After an infusion of .beta.-adrenergic antagonist propranolol, both hypoglycemia and rise in plasma cortisol and GH were prolonged. The administration of dopaminergic blocker pimozide failed to affect the plasma cortisol response but slightly suppressed the enhancement of GH release during hypoglycemia. Caution is recommended before making suggestions about neuroendocrine regulations from the data obtained after systemic administration of drugs. The hypothesis on the inhibitory role of the central .alpha.-adrenergic system on ACTH secretion suggested in rats and dogs was not confirmed by these results obtained in man.