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Effect of aeration conditions on the biosynthesis of carminomycin by actinomadura carminata

Effect of aeration conditions on the biosynthesis of carminomycin by actinomadura carminata

Antibiotiki (Moscow) 21(12): 1062-1065

The effect of aeration rate on the biosynthesis of carminomycin by A. carminata and biochemical changes in the fermentation broth on 3 complex media was studied. The organism can grow and produce the antibiotic within aeration ranges from 0.98-18.56 mgO2/l .cntdot. min. A decrease in the maximum rate of O2 dissolution up to 0.98 mgO2/l .cntdot. min resulted in some decrease in the activity level. Intensive aeration, i.e., 18.56 mgO2/l .cntdot. min, reduced the antibiotic production by 25%.

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Accession: 005217826

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