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Effect of age on the induction of intestinal tumors in mice by 1 2 di methyl hydrazine



Effect of age on the induction of intestinal tumors in mice by 1 2 di methyl hydrazine



Byulleten' Eksperimental'noi Biologii i Meditsiny 92(12): 705-707



1,2-Dimethylhydrazine was administered s.c. in a dose of 8 mg/kg bw [body weight] to 2-, 8- and 12-mo.-old female CBA mice for 25 wk. The animals were serially killed 26-35 wk after the beginning of treatment. The incidence of colon tumors in 2-mo.-old mice was always significantly lower (P < 0.001) than in 8- or 12-mo.-old mice. The incidence of tumors with invasive growth in 12-mo.-old mice was significantly higher (P < 0.05) than in 8-mo. old mice. Mathematical evaluation demonstrated the 1.8-fold shortening of the colon tumor latency period in old mice as compared to the young mice.

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