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Effect of alpha adrenergic stimulation and beta adrenergic stimulation on renal water excretion and medullary tissue cyclic amp in intact and diabetes insipidus rats



Effect of alpha adrenergic stimulation and beta adrenergic stimulation on renal water excretion and medullary tissue cyclic amp in intact and diabetes insipidus rats



Kidney International 12(2): 96-103



The effects of isoproterenol and norepinephrine were examined on renal water excretion and cyclic[c]AMP concentrations in renal medullary tissue in water-diuresing intact rats and rats with congenital pituitary diabetes insipidus (DI). The effects of isoproterenol on blood pressure (BP) and glomerular filtration rate (GFR) were similar in the intact and DI rats. In intact rats isoproterenol reversed the water diuresis, increasing urinary osmolality (UOsm) from 151 .+-. 13 to 491 .+-. 96 mOsm/kg of water (P < 0.005) as medullary cAMP concentration increased from 4.7 .+-. 0.6 to 13.9 .+-. 1.5 pmol/mg of protein (P < 0.001). In rats with DI isoproterenol did not significantly alter UOsm (192 .+-. 16 to 212 .+-. 11 mOsm/kg of water or medullary cAMP (6.1 .+-. 1.3 to 4.5 .+-. 0.6 pmol/mg of protein). The administration of exogenous vasopressin increased UOsm and medullary cAMP in the intact and DI rats. The effects of norepinephrine on BP and GFR were similar in intact and DI rats receiving a constant infusion of vasopressin. In intact rats norepinephrine decreased UOsm from 985 .+-. 189 to 295 .+-. 25 mOsm/kg of water (P < 0.02) as medullary cAMP decreased from 6.6 .+-. 0.5 to 2.1 .+-. 0.2 pmol/mg of protein (P < 0.001). In DI rats receiving vasopressin, norepinephrine was not associated with a significant decrease in either UOsm(408 .+-. 33.3 to 538 .+-. 71.8 mOsm/kg of water) or medullary cAMP (8.1 .+-. 1.2 to 14.1 .+-. 2.0 pmol/mg of protein). The primary in vivo effect of isoproterenol and norepinephrine to alter UOsm and medullary cAMP in the anesthetized rat appeared to be dependent on the modulation of endogenous vasopressin release.

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