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Effect of antigravity suit inflation on cardiovascular plasma renin activity and plasma vasopressin responses in humans



Effect of antigravity suit inflation on cardiovascular plasma renin activity and plasma vasopressin responses in humans



Journal of Applied Physiology 61(2): 766-774



Blood pressure, pulse rate (PR), serum osmolality and electrolytes, as well as plasma vasopressin (PVP) and plasma renin activity (PRA), were measured in five men and two women [mean age 38.6 .+-. 3.9 (SE) yr] before, during, and after inflation of an antigravity suit that covered the legs and abdomen. After 2 h of fluid deprivation the subjects stood quietly for 3 h: the 1st h without inflation, the 2nd with inflation to 60 Torr, and the 3rd without inflation. A similar control noninflation experiment was conducted 10 mo after the inflation experiment using five of the seven subjects except that the suit was not inflated during the 3-h period. Mean arterial pressure increased by 14 .+-. 4 (SE) Torr (P < 0.05) with inflation and decreased by 15 .+-. 5 Torr (P < 0.05) after deflation. Pulse pressure (PP) increased by 7 .+-. 2 Torr (P < 0.05) with inflation and PR decreased by 11 .+-. 5 beats/min (P < 0.05); PP and PR returned to preinflation levels after deflation. Plasma volume decreased by 6.1 .+-. 1.5% and 5.3 .+-. 1.6% (P < 0.05) during hours 1 and 3, respectively, and returned to base line during inflation. Inflation decreased PVP from 6.8 .+-. 1.1 to 5.6 .+-. 1.4 pg/ml (P < 0.05) and abolished the significant rise in PRA during hour 1. Both PVP and PRA increased significantly after deflation .DELTA.=18.0 .+-. 5.1 pg/ml and 4.34 .+-. 1.71 ng angiotensin I .cntdot. ml-1 .cntdot. h-1, respectively. Serum osmolality and Na+ and K+ concentrations were unchanged during the 3 h of standing. These data indicate a headward redistribution of blood during inflation, and the antigravity suit may provide an alternative to bed rest and water immersion for examining some early responses of humans to weightlessness.

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Accession: 005221064

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