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Effect of bcg on allo immune cell mediated cyto toxicity in c 57bl 6j female a j male f 1 mice part 1 effect of different bcg treatments on cyto toxicity mediated by thymus derived cells and macrophages



Effect of bcg on allo immune cell mediated cyto toxicity in c 57bl 6j female a j male f 1 mice part 1 effect of different bcg treatments on cyto toxicity mediated by thymus derived cells and macrophages



Journal of the National Cancer Institute 60(5): 1059-1068



The effect of BCG on the development of cell-mediated cytotoxicity (CMC) in the spleens of allogeneic tumor-bearing female (C57BL/6J.female. .times. A/J.male.)F1 mice was studied. BCG-treated tumor-bearing animals elicited a stronger CMC response than untreated tumor-bearing animals. The degree of activation was dependent on the time, route of injection and dose of BCG. If BCG was administered at suboptimal conditions, a less marked stimulation of CMC resulted. A combination of a high BCG dose given i.v. 12 days before implant of P815 mastocytoma cells and a low, 2nd dose given at the time of implant produced the most marked activation of the CMC response. By use of in vitro techniques, specific CMC was mediated by T[thymus-derived]-cells, with macrophages making a less significant contribution.

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Accession: 005222456

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