Effect of blocking bilateral jugular venous outflow on intracranial pressure, compliance and CSF outflow resistance with thiamylal and ketamine in cats

Sakuma, Y.

Masui. Japanese Journal of Anesthesiology 35(10): 1473-1481


ISSN/ISBN: 0021-4892
PMID: 3806939
Accession: 005223348

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In radical neck dissection, ligation and removal of the internal jugular veins cannot be avoided. These procedures frequently affect venous return from the cranial cavity, on occasion, resulting in serious intracranial complications such as increased intracranial pressure and cerebral edema. The effects of anesthetic technique and drugs on increase in intracranial pressure and cerebral blood flow have been studied extensively in normal subjects but not in subjects undergoing radical neck dissection. The present experimental study was designed to examine the effect of thiamylal or ketamine in cats with ligated bilateral jugular veins (ligated cats) on epidural pressure, intracranial compliance and cerebrospinal fluid (CSF) outflow resistance. Intracranial compliance and CSF outflow resistance were calculated by the method of Marmarou. The results were as follows; Thiamylal and ketamine had no effects on the intracranial compliance in normal cats. In normal cats, ketamine increased CSF outflow resistance significantly (P < 0.001), but thiamylal had no effects. Thiamylal did not change the intracranial compliance in ligated cats but ketamine decreased it significantly (P < 0.01). Thiamylal did not change the CSF outflow resistance in ligated cats but ketamine increased it significantly (P < 0.02). These results show that ketamine causes impairment of cerebrospinal fluid resorption in ligated cats.