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Effect of cardiogenic gas mixing on arterial oxygen and carbon dioxide tensions during breath holding

Effect of cardiogenic gas mixing on arterial oxygen and carbon dioxide tensions during breath holding

Journal of Applied Physiology 62(4): 1453-1459

To examine the effect of cardiogenic gas mixing on gas exchange we measured arterial tension of O2 (PaO2) and arterial tension of CO2 (PaCO2) during 3- to 5-min breath holds (BH) before and after infusing 50 ml of saline into the pericardial space (PCF) of seven anesthetized, paralyzed, mechanically ventilated dogs. During BH the ventilator was disconnected and a bias flow of 50% O2 at 4-5 l/min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina. Paired runs, alternately with the without PCF, were performed in triplicate in each dog. Initial PaO2 was similar for control runs [81 .+-. 3 mmHg (SE)] and PCF runs (78 .+-. 3 mmHg; P > 0.1). After 3-min BH, PaO2 in PCF runs (33 .+-. 3 mmHg) was less than that in control runs (58 .+-. 4 mmHg) (P < 0.001). In contrast, the pattern of PaCO2 during BH did not differ with PCF. After 3-min BH, PaCO2 was 49 .+-. 3 mmHg with PCF and 49 .+-. 2 mmHg in the control runs (P > .07). In two dogs, repeated 50-ml reductions in lung volume, produced by rib cage compression, did not alter the time course of PaO2 during BH. Although cardiac output decreased slightly with PCF, hemodynamic changes due to PCF were unlikely to account for the observed fall in PaO2. Our results indicate a substantial effect of cardiogenic gas mixing on O2 uptake when tracheal gas is O2 enriched during breath holding. This is relevant to clinical situations where hypoventilating patients breathe O2-enriched gas mixtures. However, CO2 elimination was unchanged, suggesting that, in the presence of physiological concentration gradients of gases in the airways, cardiogenic mixing does not contribute measurably to lung-blood gas exchange.

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Accession: 005225351

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