EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of cardiogenic gas mixing on arterial oxygen and carbon dioxide tensions during breath holding



Effect of cardiogenic gas mixing on arterial oxygen and carbon dioxide tensions during breath holding



Journal of Applied Physiology 62(4): 1453-1459



To examine the effect of cardiogenic gas mixing on gas exchange we measured arterial tension of O2 (PaO2) and arterial tension of CO2 (PaCO2) during 3- to 5-min breath holds (BH) before and after infusing 50 ml of saline into the pericardial space (PCF) of seven anesthetized, paralyzed, mechanically ventilated dogs. During BH the ventilator was disconnected and a bias flow of 50% O2 at 4-5 l/min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina. Paired runs, alternately with the without PCF, were performed in triplicate in each dog. Initial PaO2 was similar for control runs [81 .+-. 3 mmHg (SE)] and PCF runs (78 .+-. 3 mmHg; P > 0.1). After 3-min BH, PaO2 in PCF runs (33 .+-. 3 mmHg) was less than that in control runs (58 .+-. 4 mmHg) (P < 0.001). In contrast, the pattern of PaCO2 during BH did not differ with PCF. After 3-min BH, PaCO2 was 49 .+-. 3 mmHg with PCF and 49 .+-. 2 mmHg in the control runs (P > .07). In two dogs, repeated 50-ml reductions in lung volume, produced by rib cage compression, did not alter the time course of PaO2 during BH. Although cardiac output decreased slightly with PCF, hemodynamic changes due to PCF were unlikely to account for the observed fall in PaO2. Our results indicate a substantial effect of cardiogenic gas mixing on O2 uptake when tracheal gas is O2 enriched during breath holding. This is relevant to clinical situations where hypoventilating patients breathe O2-enriched gas mixtures. However, CO2 elimination was unchanged, suggesting that, in the presence of physiological concentration gradients of gases in the airways, cardiogenic mixing does not contribute measurably to lung-blood gas exchange.

(PDF emailed within 1 workday: $29.90)

Accession: 005225351

Download citation: RISBibTeXText



Related references

Effect of cardiogenic gas mixing on arterial O2 and CO2 tensions during breath holding. Journal of Applied Physiology 62(4): 1453-1459, 1987

Arterial oxygen tensions, not carbon dioxide tensions, have influence on ophthalmic artery flow velocities in very preterm infants. Pediatric Research 33(4 PART 2): 201A, 1993

Assessment of a single-breath method for determining carbon dioxide tensions in mixed venous and arterial blood in the dog. Journal of Physiology 290(2): 52p-53p, 1979

Composition of alveolar air during breath holding with and without prior inhalation of oxygen and carbon dioxide. Journal of Applied Physiology 7(3): 313-319, 1954

Arterial Carbon Dioxide And Oxygen Tensions During Spinal Block. JAMA 191: 698-702, 1965

Changes in arterial and transcutaneous oxygen and carbon dioxide tensions during and after voluntary hyperventilation. Respiration; International Review of Thoracic Diseases 64(3): 200-205, 1997

Estimation of arterial oxygen and carbon dioxide tensions by a single transcutaneous sensor. Archives of Disease in Childhood 60(4): 356-359, 1985

Arterial oxygen and carbon dioxide tensions in conscious laterally recumbent ponies. Equine Veterinary Journal 16(3): 185-188, 1984

Oxygen and carbon dioxide tensions of arterial blood during heavy and exhaustive exercise. Acta Physiologica Scandinavica 44(3-4): 203-215, 1958

Method for determination of partial tensions of oxygen & carbon dioxide in arterial blood. Revista Medica de Chile 85(5): 259-261, 1957

Accuracy of routine arterial puncture for the determination of oxygen and carbon dioxide tensions. American Review of Respiratory Disease 106(5): 776-779, 1972

Normal arterial blood pH, oxygen, and carbon dioxide tensions in unanesthetized dogs. Journal of Applied Physiology 32(1): 152-153, 1972

End tidal respiratory gas pressure, oxygen intake and carbon dioxide output during the first minute after diving or breath holding in water. Pflugers Archiv 307(2): R93-R93, 1969

Oxygen and carbon dioxide tensions in the canine kidney during arterial occlusion and hemorrhagic hypotension. Surgery, Gynecology & Obstetrics 158(1): 27-32, 1984

Variations of arterial oxygen and carbon dioxide tensions during 24 hours in chronic respiratory insufficiency. Scandinavian Journal of Respiratory Diseases 55(2): 99-104, 1974