Effect of central dopamine, histamine & 5-hydroxytryptamine on stress-induced gastric ulceration in rats

Gupta, M.B.; Gupta, G.P.; Bhargava, K.P.

Indian Journal of Medical Research 78: 281-283


ISSN/ISBN: 0019-5340
PMID: 6654419
Accession: 005225798

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Restraint for 2 h at 4.degree. C or 6 h at room temperature (26.degree. .+-. 2.degree. C) induced gastric ulceration in 92 and 30% of albino rats, respectively. Intracerebroventricular administration of dopamine, histamine and 5-hydroxytryptamine (5-HT) did not inhibit the maximal ulcerogenic response induced by cold and restraint. However, the minimal ulcerogenic response at room temperature was significantly enhanced by 5-HT but not by dopamine and histamine. 5-HT in the CNS seems to play a facilitatory role in stress-induced gastric ulceration.