Effect of central prostaglandins in stress-induced gastric ulceration in rats

Gupta, M.B.; Gupta, G.P.

Indian Journal of Medical Research 87: 637-640

1988


ISSN/ISBN: 0019-5340
PMID: 3240944
Accession: 005225809

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Abstract
Restraint for 2 h at 47% or 6 h at room temperature (30.degree. C) induced gastric ulceration in 90 and 30 per cent of albino rats respectively. Prostaglandin E2 (PGE2 5, 10 and 20 .mu.g) injected intracerebroventricularly (icv) showed dose-dependent reduction of gastric ulceration induced by cold-restraint (CRU) whereas on intraperitoneal administration 400 .mu.g of PGE2 was requied to inhibit CRU. Phenylbutazone sodium (150 .mu.g, icv), a prostaglandin synthetase inhibitor per se did not induce gastric ulceration in normal rats but significantly enhanced the minimal ulcerogenic response induced by 6 h restraint at room temperature. Prostaglandin F2.alpha. (PGF2.alpha.) 5, 10 and 20 .mu.g icv or 200-400 .mu.g ip neither altered the incidence of CRU nor enhanced the minimal ulcerogenic response induced by 6 h restraint at room temperature (30.degree. C). In the CNS PGE2 seems to play an inhibitory role in stress-induced gastric ulceration.