Effect of coronary sinus occlusion on coronary circulation and hemodynamics 2. effect of coronary sinus occlusion on coronary pressure flow relations during vagal arrest in anesthetized open chest dogs comparison between the left anterior descending artery and the left circumflex artery

Nishiyama, O.

Okayama Igakkai Zasshi 96(1-2): 101-108


ISSN/ISBN: 0030-1558
Accession: 005229492

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Effect of coronary sinus (CS) occlusion on pressure-flow relations was studied at peak reactive hyperemia in anesthetized open-chest dogs during vagal arrest. CS was closed by a specially designed balloon cather. The pressure-flow relations were lineal in both the left anterior descending coronary artery (LAD) and the left circumflex coronary artery (LCX). With CS occlusion, the pressure-flow relations did not change in slope, but shifted to the right in both LAD and LCX. The zero-flow pressure intercept (PF = 0) was 22 .+-. 4 mm Hg in LAD and 17 .+-. 6 mm Hg in LCX with the CS open. There was no significant difference in the PF = 0 between LAD and LCX. The PF = 0 varied directly with changes in CS pressure caused by CS occlusion. Two variables fitted closer in LCX than LAD. Even a slight elevation in CSP affected PF = 0. CSP probably works as an extravascular compression rather than as a perfusion pressure.