Effect of corticosteroids on sciatic nerve-tibialis anterior muscle of rats treated with hemicholinium-3. An experimental approach to a possible mechanism of action of corticosteroids in myasthenia gravis

Leeuwin, R.S.; Wolters, E.C.

Neurology 27(2): 171-177


ISSN/ISBN: 0028-3878
PMID: 189257
Accession: 005229540

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The effect of i.p. administered corticosteroids was studied on the neuromuscular transmission in the sciatic nerve-tibialis anterior muscle preparation of the anesthetized rat stimulated at a rate of 10 Hz. Administered simultaneously with hemicholinium-3 (HC-3), 80 .mu.g/kg (half the LD50), prednisolone and dexamethasone caused a marked reversal of the block of the neuromuscular transmission caused by HC-3. Aldosterone's effect was very small. The blocking action of d-tubocurarine was not antagonized by either prednisolone or dexamethasone. Choline provided total protection against the HC-3 blockade; physostigmine, in a sublethal dose, was ineffective. In myasthenia gravis the carrier-mediated transport of choline into the nerve endings may be deficient and the beneficial effect of corticosteroids in this condition is probably based on their ability to ameliorate the deficient choline transport.