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Effect of dietary alpha linolenic acid and gamma linolenic acid on tissue fatty acids in guinea pigs

Effect of dietary alpha linolenic acid and gamma linolenic acid on tissue fatty acids in guinea pigs

Proceedings of the Society for Experimental Biology & Medicine 178(1): 46-49

Guinea pigs were fed regular chow diets supplemented with 5% (by wt) safflower oil, evening primrose oil or linseed oil for 6 wk. The unsaturated fatty acid content of these oils was 78.9% of 18:2n6, 74.1% of 18:2n6, and 9.2% of 18:3n6 or 21.5% of 18:2n6 and 46.9% of 18:3n3, respectively. In comparison with 18:2n6, dietary supplementation with 18:3n6 significantly increased the tissue levels of 18:3n6; and 20:3nb, dietary 18:3n3 significantly elevated the levels of 18:3n3 in plasma and liver lipids. Dietary 18:3n3 also significantly increased 22:5n3 and 22:6n3 in total phospholipids. The tissue levels of 20:4n6 were not affected by either treatment. Apparently both .DELTA.6- and .DELTA.5-desaturation of n-6 fatty acids in guinea pigs are low, and the metabolism of n-3 and n-6 fatty acids may be regulated by 2 different enzyme systems.

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