Effect of dietary cholesterol on serum cholesterol level and bile acid metabolism in streptozotocin diabetic rats
Yonago Acta Medica 29(1): 34-48
The serum cholesterol level and the metabolism of bile acids in streptozotocin-diabetic rats fed on a standard diet were compared with those fed on a cholesterol-deficient diet. Hypercholesterolemia was induced in rats with advanced diabetes, while not in those with milder diabetes. Restriction of dietary cholesterol could prevent diabetic rats from suffering from hypercholesterolemia. In diabetic rats, the biliary excretion and the enterohepatic pool of bile acids were greater than those in control rats. The percentage of cholic acid increased in the composition of total bile acids. Changes in the metabolism of bile acids were found in both the diabetic rats with and without hypercholesterolemia. In rats with advanced diabetes, there was a decrease in the ratio of taurine conjugates in biliary bile acids.