+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effect of dietary trans fatty acids on the delta 5 desaturase delta 6 desaturase and delta 9 desaturase of rat liver microsomes in vivo

Effect of dietary trans fatty acids on the delta 5 desaturase delta 6 desaturase and delta 9 desaturase of rat liver microsomes in vivo

Acta Biologica et Medica Germanica 40(12): 1699-1706

ISSN/ISBN: 0001-5318

Male rats [3 groups] were studied to assess the effects of trans fatty acids on the desaturases of rat liver microsomes in vivo. The trans fatty acids fed rats showed significant decrease in the activities of .DELTA.9 (P < 0.001) and.DELTA.6 (P < 0.01) desaturase was normal as compared to the control group. The group of rats fed hydrogenated coconut oil showed only significant decrease in their liver microsomal .DELTA.9 desaturase (P < 0.05), whereas .DELTA.5 and .DELTA.6 desaturases were within the normal level of the control group. The level of trans fatty acids accumulated into the microsomal lipids of trans-fed rats reached to .apprx. 15.6% of their total fatty acids, of which 12.6% were represented as trans-18:1 acid. The trans-.DELTA.9, .DELTA.10, .DELTA.11 and .DELTA.12 18:1 isomers were the major isomers accumulated into the microsomes. The trans-.DELTA.5, .DELTA.6, .DELTA.7,.DELTA.15 and .DELTA.16 18:1 isomeres were detected only in small amounts ranging from 0.9-2.0%. The dietary trans fatty acids apparently are differentially incorporated into the liver microsomal lipids and act as inhibitors for .DELTA.9 and .DELTA.6 desaturases. The .DELTA.6 desaturase is considered as the key enzyme in the conversion of the essential fatty acids to arachidonic acid and prostaglandins. The presence of trans fatty acids in the diet may induce some effects on the EFA [essential fatty acid] metabolism through their action on the desaturases.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 005233223

Download citation: RISBibTeXText

Related references

Immunochemical evidence for the enzymatic difference of delta 6-desaturase from delta 9- and delta 5-desaturase in rat liver microsomes. Biochemical and Biophysical Research Communications 110(1): 36-41, 1983

Solubilization of linoleoyl-coenzyme A desaturase of rat liver microsomes: evidence of different responses of delta 6- and delta 9-desaturase to detergents. Febs Letters 104(2): 241-243, 1979

Delta 9 desaturase and delta 6 desaturase activities of the ovine placenta and their role in the supply of fatty acids to the fetus. Biology of the Neonate 36(5-6): 298-304, 1979

Effects of dietary omega 3 fatty acids and cholesterol on delta 6 desaturase activity in rat liver microsomes. Journal of the American Oil Chemists' Society 64(5): 667, 1987

Effect of dietary fatty acids on delta 5 desaturase activity and biosynthesis of arachidonic acid in rat liver microsomes. Lipids 18(11): 781-788, 1983

Cold induced increase of delta 9 desaturase and delta 6 desaturase activities in endoplasmic membranes of carp cyprinus carpio liver. Biochimica et Biophysica Acta 734(1): 70-75, 1983

Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. Journal of Nutrition 118(6): 661-668, 1988

Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris. Plant Molecular Biology 54(3): 335-352, 2004

Effect of dietary trans fatty acids on the delta 5, delta 6 and delta 9 desaturases of rat liver microsomes in vivo. Acta Biologica et Medica Germanica 40(12): 1699-1705, 1981

Selective reduction of delta 6 and delta 5 desaturase activities but not delta 9 desaturase in micropigs chronically fed ethanol. Journal of Clinical Investigation 93(1): 450-454, 1994

Conversion of Essential Fatty Acids by Delta 6-Desaturase in Dog Liver Microsomes. The Journal of Nutrition 132(6): 1701S-1703S, 2002

Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. Journal of Nutrition 132(6 Suppl 2): 1701s-1703s, 2002

Delta-6-desaturase and delta-5-desaturase in human Hep G2 cells are both fatty acid interconversion rate limiting and are upregulated under essential fatty acid deficient conditions. Prostaglandins Leukotrienes and Essential Fatty Acids 56(6): 437-442, 1997

Effects of dietary protein and EFA deficiency on liver delta 5, delta 6 and delta 9 desaturase activities in the early developing rat. Journal of Nutrition 110(4): 595-599, 1980

Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. Biochimica et Biophysica Acta 962(3): 330-336, 1988