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Effect of dietary trans fatty acids on the delta 5 desaturase delta 6 desaturase and delta 9 desaturase of rat liver microsomes in vivo


Effect of dietary trans fatty acids on the delta 5 desaturase delta 6 desaturase and delta 9 desaturase of rat liver microsomes in vivo



Acta Biologica et Medica Germanica 40(12): 1699-1706



ISSN/ISBN: 0001-5318

Male rats [3 groups] were studied to assess the effects of trans fatty acids on the desaturases of rat liver microsomes in vivo. The trans fatty acids fed rats showed significant decrease in the activities of .DELTA.9 (P < 0.001) and.DELTA.6 (P < 0.01) desaturase was normal as compared to the control group. The group of rats fed hydrogenated coconut oil showed only significant decrease in their liver microsomal .DELTA.9 desaturase (P < 0.05), whereas .DELTA.5 and .DELTA.6 desaturases were within the normal level of the control group. The level of trans fatty acids accumulated into the microsomal lipids of trans-fed rats reached to .apprx. 15.6% of their total fatty acids, of which 12.6% were represented as trans-18:1 acid. The trans-.DELTA.9, .DELTA.10, .DELTA.11 and .DELTA.12 18:1 isomers were the major isomers accumulated into the microsomes. The trans-.DELTA.5, .DELTA.6, .DELTA.7,.DELTA.15 and .DELTA.16 18:1 isomeres were detected only in small amounts ranging from 0.9-2.0%. The dietary trans fatty acids apparently are differentially incorporated into the liver microsomal lipids and act as inhibitors for .DELTA.9 and .DELTA.6 desaturases. The .DELTA.6 desaturase is considered as the key enzyme in the conversion of the essential fatty acids to arachidonic acid and prostaglandins. The presence of trans fatty acids in the diet may induce some effects on the EFA [essential fatty acid] metabolism through their action on the desaturases.

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Accession: 005233223

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