Effect of different elastase inhibitors on leukocyte elastase ec 3.4.21.11 pre adsorbed to elastin

Hornebeck, W.; Schnebli, H.P.

Hoppe Seyler's Zeitschrift fuer Physiologische Chemie 363(4): 455-458

1982


Accession: 005233539

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
The effect of 3 elastase inhibitors (MeO-Suc-Ala-Ala-Pro-Val-CH2Cl, eglin c and .alpha.1-proteinase inhibitor) on the hydrolysis of [3H]elastin was determined. The low-molecular mass inhibitors inactivated elastase nearly completely, regardless of whether or not the enzyme was adsorbed to its substrate elastin prior to the addition of the inhibitors. Elastase preadsorbed to elastin was much less sensitive to the inhibitory effect of .alpha.1-proteinase inhibitor than the free elastase.