Effect of etoperidone on the depletion of brain 5-hydroxytryptamine and catecholamines induced respectively by p-chloromethamphetamine and 6-hydroxydopamine in rats

Carruba, M.O.; Parenti, M.; Ricciardi, S.; Picotti, G.B.; Mantegazza, P.

Pharmacological Research Communications 11(2): 169-177


ISSN/ISBN: 0031-6989
PMID: 155821
Accession: 005237467

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Etoperidone, as well as chlorimipramine, were able to antagonize the brain 5-hydroxytryptamine (5-HT) depletion induced by p-chloromethamphetamine and to decrease the rat brain 5-hydroxyIAA concentrations. Etoperidone and desipramine (DMI) did not antagonize the decrease of brain dopamine induced by 6-hydroxydopamine (6-OHDA) whereas only DMI counteracted the 6-OHDA-induced brain norepinephrine depletion. These data would indicate that etoperidone specifically blocks in vivo 5-HT reuptake mechanisms and that this effect may be also responsible for a compensatory reduction of 5-HT turnover.