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Effect of fetal thymectomy on immuno globulin g immuno globulin m and immuno globulin a concentrations in sheep



Effect of fetal thymectomy on immuno globulin g immuno globulin m and immuno globulin a concentrations in sheep



American Journal of Veterinary Research 37(10): 1139-1141



Serum concentrations of immunoglobulins (Ig) IgG1, IgG2, IgM and IgA were compared for normal and thymectomized lambs. Fetal thymectomies were performed in utero at 55-67 days of gestation. High serum IgG1, IgM and IgA concentrations occurred in all lambs after they ingested colostrum. The concentration of these Ig, as measured by single radial immunodiffusion, decreased exponentially during the first 16 days after birth. The 1/2-life values for IgG1, IgM and IgA during this period in normal and thymectomized lambs were about 25, 6 and 2 days, respectively. Increasing amounts of IgG2 were not detected in the sera of either group until 1 mo. of age. At 64-128 days, significantly smaller quantities of IgG1 and IgG2 were found in thymectomized lambs; concentrations of IgA and IgM were similar in both groups. The thymus may regulate production of IgG in sheep.

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Accession: 005239201

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