+ Translate

Effect of fish oil concentrates on hemorheological and hemostatic aspects of diabetes mellitus a preliminary study

, : Effect of fish oil concentrates on hemorheological and hemostatic aspects of diabetes mellitus a preliminary study. Thrombosis Research 47(2): 201-214

Fish oil concentrates (Max EPA) were given without other diet modification for eight weeks to five insulin-dependent diabetics and five healthy volunteers, in order to determine their effect on possible in vitro indices of thrombosis. Cholesterol, HDL, LDL, fasting blood sugar, hemoglobin A1c, platelet count, and the osmotic fragility of red blood cells were not significantly changed from baseline values after eight weeks of fish oil consumption. Serum triglyceride levels were lowered by the fish oil (diabetics 130 .+-. 23 to 89 .+-. 26 mg/dl: normals 107 .+-. 16 to 57 .+-. 5 mg/dl-). Nine out of ten subjects required more arachiconic acid to aggregate their platelets, and six out of ten required more collagen. Whole blood viscosity at lower shear rates was increased in diabetics before the fish oil ingestion, and was reduced both in normals and in diabetics after eight weeks of treatment. Before fish oil administration, the diabetics had higher levels of von Willebrand Factor (vWF) (208 .+-. 31%) than did controls (117 .+-. 26%). There was a statistically significant decrease of serum von Willebrand Factor both in diabetics (p < 0.01) and in normals (p < 0.05) after six weeks of treatment. Analysis of the multimeric composition of the vWF indicated that the vWF molecule was not altered. Addition of eicosapentaenoic acid (EPA) or crude fish oil to human umbilical cord endothelial cell cultures did not change vWF levels in the supernatant. Whether these changes in platelet aggregation, whole blood viscosity and vWF can actually be translated into an in vivo amilioration of the vascular complications in diabetes remains to be determined in a carefully controlled clinical trial.

Accession: 005239325

PMID: 3499006

DOI: 10.1016/0049-3848(87)90377-x

Download PDF Full Text: Effect of fish oil concentrates on hemorheological and hemostatic aspects of diabetes mellitus a preliminary study

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Cho, M.; Shin, S.; Kwon, H.Moon.; Chung, H.; Lee, B.Kwon., 2015: Effect of clinical and RBC hemorheological parameters on myocardial perfusion in patients with type 2 diabetes mellitus. Myocardial ischemia may be present even when there is no significant stenosis of the epicardial coronary artery, or after coronary angioplasty for significant coronary artery disease. This phenomenon is related to disturbance of the coronary micro...

Harbarchuk, O.I.; Malyzhev, V.O., 2002: Specific aspects of heparin action on hemostatic reaction in patients with type II diabetes mellitus before and after the foot surgery. Results of surgical treatment of 15 patients with diabetes mellitus of type II, complicated by gangrene of foot, were analyzed. It was established, that conduction of heparinotherapy after performance of surgical intervention for diabetic foot may...

Purnell, J.Q.; Zinman, B.; Brunzell, J.D., 2013: The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. Intensive diabetes mellitus therapy of type 1 diabetes mellitus reduces diabetes mellitus complications but can be associated with excess weight gain, central obesity, and dyslipidemia. The purpose of this study was to determine whether excessive...

Petrukhin, V.A.; Efimov, V.S.; Fedorova, M.V.; Grishin, V.L.; Kotov, I.B., 1995: The importance of study of the hemostatic system for the management of pregnant women with diabetes mellitus. Klinicheskaia Laboratornaia Diagnostika: 87-89

Uchimura, I., 1997: Hemorheological abnormality in diabetes mellitus. Nihon Rinsho. Japanese Journal of Clinical Medicine 55 Suppl: 688-693

Cho, Y.I.; Mooney, M.P.; Cho, D.J., 2009: Hemorheological disorders in diabetes mellitus. The objective of the present study is to review hemorheological disorders in diabetes mellitus. Several key hemorheological parameters, such as whole blood viscosity, erythrocyte deformability, and aggregation, are examined in the context of eleva...

Cella A.; Bianchi E.; Reali G.L.; Piana A.; Armani U., 1990: Evaluation of some hemorheological parameters in diabetes mellitus. It has been speculated that changes in intrinsic blood flow properties may contribute to the evolution of vascular complications in diabetes mellitus. To verify this hypothesis we measured hematocrit, fibrinogen, plasma and blood viscosity in 30 d...

Uchimura I.; Morochosi M.; Fujisawa K., 1992: Interleukin 6 and its hemorheological effects in diabetes mellitus. Biorheology 29(1): 27

Puniyani R.R.; Chandalia H.B.; Annapurna V., 1991: Treatment modalities and hemorheological patterns in diabetes mellitus. Clinical Hemorheology 11(3-4): 243-250

L.D.vehat, C.; Khodabandehlou, T.; Vimeux, M., 1994: Relationship between hemorheological and microcirculatory abnormalities in diabetes mellitus. From numerous studies, it is now well known that diabetes mellitus is usually accompanied by miscellaneous hemorheological disturbances. These may alter the microcirculatory flow and lead ultimately to tissue chronic hypoxia. In this report, red b...