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Effect of fluoride on major salivary glands the amylase activity stimulated salivary flow response and cyclic amp levels in parotid gland of rats consuming fluoride ion via drinking water


Fluoride 17(4): 217-223
Effect of fluoride on major salivary glands the amylase activity stimulated salivary flow response and cyclic amp levels in parotid gland of rats consuming fluoride ion via drinking water
The effect of intakes of 25 or 50 ppm fluoride [F-] via drinking water for 4 wk on the amylase activity of the parotid gland, isoproterenol-stimulated (1 mg/100 g body wt, i.p.) salivary flow and amylase activity in saliva fractions was examined. A significant elevation of the tissue amylase activity was seen in the 25 or 50 ppm F- and groups compared to control. The volume of saliva collected for 30 min after isoproterenol injection was higher in the F- treated groups; the amylase activity was also increased. In the glandular tissue cAMP level was augmented. F- may have affected the parotid function; it may also have influenced the salivary amylase activity, presumably by acting on the adenylate cyclase activity.


Accession: 005239549



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