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Effect of fluoro carbon blood substitute on peripheral blood lymphocyte transformation in monkeys and guinea pigs



Effect of fluoro carbon blood substitute on peripheral blood lymphocyte transformation in monkeys and guinea pigs



Acta Pharmacologica Sinica 3(4): 283-286



The effect of perfluorocarbon emulsion (PFE) on mitogen phytohemagglutinin (PHA)-induced proliferative responses of peripheral blood lymphocytes was examined in rhesus monkeys and guinea pigs. [3H]TdR [thymidine] incorporation was followed to reflect lymphocyte transformation. Responses to PHA of the peripheral blood lymphocytes of 4 monkeys from i.v. infusion of PFE (60 ml/kg) were insignificant comparing with the pre-infusion. The lymphocyte transformation index (LTI) in 24 h after infusion of PFE was markedly elevated. Infusion of 7-10 ml 25% PFE resulted in a half-dilution of the blood volumes in guinea pigs. Peripheral blood lymphocytes were cultured on day 3, 7, 11 and 15 to determine the response to PFE by measuring the uptake of [3H]TdR. After day 7 of exchange-transfusion, LTI to PHA were significantly increased. Evidently, PFE stimulates cellular immune system.

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Accession: 005239600

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PMID: 6219549



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