EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of folic acid on the activity of the monooxygenase system udp glucuronyl and glutathione s transferases in normal and regenerating rat liver tissue



Effect of folic acid on the activity of the monooxygenase system udp glucuronyl and glutathione s transferases in normal and regenerating rat liver tissue



Voprosy Meditsinskoi Khimii 33(4): 93-95



After administration into rats of the folic acid at a dose of 25 mg/kg within 14 days activities of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases, content of cytochromes P-450 and b5 as well as the rates of NADPH and NADH oxidation were increased in liver microsomes. The stimulating action of the vitamin was also observed within later periods of liver tissue regeneration during 8 days after partial hepatectomy. Content of cytochrome b5, binding of cytochrome P-450 with aniline, N-demethylation of ethylmorphine as well as activities of UDP-glucuronyl- and glutathione-S-transferases were increased by 23-46% after the treatment as compared with control partially hepatectomized animals. At the period high mitotic activity of hepatocytes, within 2 days after the operation, the vitamin did not affect the parameters studied.

(PDF 0-2 workdays service: $29.90)

Accession: 005239741

Download citation: RISBibTeXText



Related references

Effect of folic acid on the activity of monooxygenase system, UDP-glucuronyl- and glutathione-S-transferase in the normal and regenerating rat liver. Voprosy Meditsinskoi Khimii 33(4): 93-95, 1987

The effect of folic acid and methotrexate on the activity of the glucuronyl- and glutathione-conjugating systems of the liver in rats. Farmakologiia i Toksikologiia 52(5): 47-50, 1989

Protective effect of essentiale combination with diethyl nicotinamide on rat liver monooxygenases, glucuronyl transferases and glutathione transferases of tetrachloromethane-affected liver of rats. Eksperimental'naya i Klinicheskaya Farmakologiya 57(4): 62-63, 1994

Steroid glucuronyl transferases of rat liver properties of estrone and testosterone glucuronyl transferases and the effect of ovariectomy castration and administration of steroids on the enzymes. Biochemical Journal 162(3): 545-556, 1977

Effects of folic acid and methotrexate on the activities of the rat liver glucuronyl and glutathione conjugating systems. Farmakologiya i Toksikologiya (Moscow) 52(5): 47-50, 1989

Effects of folic acid and methotrexate on arginase activity in regenerating rat liver tissue. Archives Internationales de Physiologie, de Biochimie et de Biophysique 101(5): 271-273, 1993

Comparative studies of the effect of nicotinamide and diethylnicotinamide on the liver monooxygenase glucuronyl and glutathione conjugating systems. Byulleten' Eksperimental'noi Biologii i Meditsiny 110(12): 633-635, 1990

The effect of nicotinamide on the activity of the glutathione- glutathione reductase system in subcellular fractions of regenerating rat liver. Ukrainskii Biokhimicheskii Zhurnal 61(5): 54-59, 1989

The effect of nicotinamide on the activity of glutathione glutathione reductase system in subcellular fractions of the regenerating rat liver. Ukrainskii Biokhimicheskii Zhurnal 61(5): 54-59, 1989

Possibility of experimental induction of the microsomal monooxygenase system of the liver to a minimum (quantitative and activity) level. The effect of hypophysectomy, partial hepatectomy and phenobarbital administration on the polysubstrate monooxygenase system of the liver in rats. Morphologiai Es Igazsagugyi Orvosi Szemle 22(4): 247-260, 1982

The protective action of a combination of essentiale with diethylnicotinamid on rat liver mono-oxygenases and glucuronyl- and glutathione transferases in a trichloromethane lesion. Eksperimental'naia i Klinicheskaia Farmakologiia 57(4): 62-63, 1994

Effect of antioxidants on the activity of liver glutathione-S-, glucuronyl- and sulfurtransferases in rats. Farmakologiia i Toksikologiia 50(3): 81-84, 1987

Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases. European Journal Of Biochemistry. 231(2): 337-343, 1995

The effect of heparin on the activity of the mono-oxygenase glucuronyl- and glutathione transferase systems in ultrasonic damage to the rat liver. Eksperimental'naia i Klinicheskaia Farmakologiia 60(2): 42-44, 1997