EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of follicle stimulating hormone and estrogen on follicle growth in rats


Archiv fuer Gynaekologie 222(4): 333-344
Effect of follicle stimulating hormone and estrogen on follicle growth in rats
The effect of FSH and diethylstilbestrol (DES) on ovarian follicle growth was studied in hypophysectomized rats, using histologic, autoradiographic and histochemical techniques. The administration of FSH to immature hypophysectomized rats stimulated the follicle growth with thickening of the theca layer and repair of deficiency cells. Although DES given to hypophysectomized rats also stimulated the follicle growth, the theca layer was relatively thin compared with that in FSH-treated rats. To detect cell division in a growing follicle, the number of labeled granulosa cells with 3H-thymidine as a proportion of the granulosa cells in a growing follicle were counted and the labeling indices of the granulosa cells were calculated. The labeling indices increased by the administration of FSH (P < 0.05) or DES (P < 0.05). The uptake of 3H-thymidine and leucine by the theca cells was enhanced only by FSH and was not stimulated by DES. The administration of FSH resulted in an increase of the histochemically demonstrable enzyme activity such as .DELTA.5-3.beta.-hydroxysteroid dehydrogenase (3.beta.-HSD) or alkaline phosphatase in the theca cells. The administration of DES did not stimulate the enzyme activity of the theca cells. FSH stimulated a release of estradiol and estriol from the ovary of hypophysectomized rat, whereas DES did not. Although ovarian follicle growth was stimulated by FSH and DES, the effect of the 2 hormones on the theca cells was quite different, and the secretion of estrogen was stimulated by FSH. FSH induced follicle growth of the ovary might be mediated by estrogen produced by the theca cells.


Accession: 005239750



Related references

Effect of follicle-stimulating hormone (FSH) and estrogen on follicle growth in rats. Archiv fur Gynakologie 222(4): 333-344, 1976

Effect of follicle-stimulating hormone (FSH) and estrogen on follicle growth in rats. Archiv für Gynakologie 222(4): 333-344, 1977

The mechanism of follicle growth part 1 the effect of follicle stimulating hormone luteinizing hormone and estrogen on follicle growth. Folia Endocrinologica Japonica 53(10): 1159-1168, 1977

The mechanism of follicle growth. I. The effect of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estrogen on follicle growth. Nihon Naibunpi Gakkai Zasshi 53(10): 1159-1168, 1977

Estrogen and follicle stimulating hormone interactions on follicle growth in rats. Endocrinology 90(6): 1492-1498, 1972

Effect of clomiphene metab upon plasma follicle stimulating hormone activity and hypothalamic follicle stimulating hormone releasing factor content in ovariectomized estrogen metab progesterone metab blocked rats. Endocrinology 84: 946, 1969

Combined effect of follicle-follicle interactions and declining follicle-stimulating hormone on murine follicle health in vitro. Biology of Reproduction 65(4): 1304-1310, 2001

Effect of castration or testosterone metab treatment on hypothalamic follicle stimulating hormone releasing factor and pituitary follicle stimulating hormone of male rats. Proceedings of the Society for Experimental Biology & Medicine 130(4): 1075-1079, 1969

Early follicle growth in the juvenile macaca monkey ovary: the effects of estrogen priming and follicle-stimulating hormone. Biology of Reproduction 50(3): 686-694, 1994

Effect of synthetic luteinizing hormone and follicle stimulating hormone releasing hormone on serum levels of luteinizing hormone follicle stimulating hormone thyrotropin and growth hormone in normal male subjects. Acta Endocrinologica 73(3): 465-474, 1973