EurekaMag.com logo
+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of follicle stimulating hormone and testosterone propionate on spermatogenesis in the hypophysectomized immature male rat



Effect of follicle stimulating hormone and testosterone propionate on spermatogenesis in the hypophysectomized immature male rat



Japanese Journal of Animal Reproduction 26(4): 165-173



Immature male rats hypophysectomized at 26 days of age were injected s.c. with FSH [follicle stimulating hormone] (200 .mu.g), testosterone propionate (TP, 800 .mu.g) and FSH (200 .mu.g) plus TP (800 .mu.g) once a day for 50 consecutive days after an interim of 30 days from hypophysectomy. They were examined for the effects of these hormones on spermatogenesis. The testes increased slightly in weight in rats treated with FSH or TP alone, as compared with those of hypophysectomized control rats. Further weight gain was achieved by administration of FSH plus TP. Spermatogenesis was arrested at the primary spermatocyte stage in 99.5% of the seminiferous tubules in rats treated with FSH or TP alone. In the group of rats injected simultaneously with FSH and TP, there were a few seminiferous tubules containing step 19 spermatids and a remarkable increase was observed in step 7 spermatids, as compared with the group injected with FSH or TP alone. The development of spermatocytes in transitional form and the process of metamorphosis from step 17 spermatids were very poor in the rats treated with FSH plus TP, as compared with the intact rats of a normal control group at 107 days of age. A few spermatozoa appeared in smears prepared from the cauda epididymidis of the rats treated with FSH plus TP. Most carried degenerative characteristics. Androgen concentrations of blood in the rats treated with TP, and FSH plus TP (testosterone; 23.7 and 18.0 ng/ml, and dihydrotestosterone [DHT]; 0.98 and 1.72 ng/ml, respectively) were higher than those in the rats treated with FSH alone and in control rats at 107 days after hypophysectomy. The conversion system of testosterone to DHT in addition to the direct effects of FSH and TP might play an important role for the production of spermatozoa and preservation of their fertilizing capacity. Spermatozoa were produced by simultaneous injection with FSH and TP for a long time, but they were small in number and lacking in viability.

(PDF emailed within 1 workday: $29.90)

Accession: 005239752

Download citation: RISBibTeXText



Related references

Effect of follicle stimulating hormone and luteinizing hormone on plasma testosterone levels in adult and immature hypophysectomized male rats. Biology of Reproduction 9(1): 101, 1973

Effects of follicle stimulating hormone and luteinizing hormone on plasma testosterone levels in hypophysectomized and in intact immature and adult male rats. Journal of Endocrinology 61(2): 193-198, 1974

Effects of testosterone propionate 5 alpha di hydro testosterone propionate and estradiol benzoate on serum levels of luteinizing hormone and follicle stimulating hormone in the castrated adult male rat. Acta Endocrinologica: 643-654, 1974

Studies in testicular function part 1 quantitative effects of follicle stimulating hormone luteinizing hormone testosterone and di hydro testosterone on restoration and maintenance of spermatogenesis in the hypophysectomized rat. Australian Journal of Biological Sciences 27(1): 47-57, 1974

Effect of neuraminidase treatment on the biological activity of highly purified ovine follicle stimulating hormone and luteinizing hormone in hypophysectomized immature male and female rats. Endocrinology 98(1): 105-110, 1976

Plasma follicle stimulating hormone releasing factor in hypophysectomized rats after treatment with testosterone propionate hormone metab or reserpine cent depress abstract. Proc Int Union Physiol Sci 7(24): 112, 1968

Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology 129(4): 1926-1932, 1991

Role of follicle-stimulating hormone in spermatogenesis in hypophysectomized adult male rats. National Institute of Animal Health Quarterly 14(4): 199-205, 1974

The effect of a single injection of testosterone propionate and estradiol benzoate on the luteinizing hormone releasing hormone induced release of follicle stimulating hormone and luteinizing hormone in the male rat. Endokrinologie 68(3): 267-274, 1976

Effect Of Follicle-Stimulating Hormone And Interstitial Cell-Stimulating Hormone On Spermatogenesis In Long-Evans Rats Hypophysectomized For Six Months. Acta Endocrinologica 43: 592-600, 1963

Modulation of prolactin luteinizing hormone and follicle stimulating hormone secretion by luteinizing hormone releasing hormone and bromocriptine cb 154 in the hypophysectomized pituitary grafted male rat and its effect on testicular luteinizing hormone receptors and testosterone output. Biology of Reproduction 21(1): 141-148, 1979

Modulation of prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion by LHRH and bromocriptine (CB154) in the hypophysectomized pituitary-grafted male rat and its effect on testicular LH receptors and testosterone output. Biology of Reproduction 21(1): 141-147, 1979

Effects of testosterone propionate or di hydro testosterone propionate on plasma follicle stimulating hormone and luteinizing hormone levels in neo natal rats and on sexual differentiation of the brain. Endocrinology 97(3): 709-717, 1975

Effects of follicle stimulating hormone and luteinizing hormone on plasma testerone levels in hypophysectomized and in intact immature and adult male rats. Journal of Endocrinology 61(2): 193-198, 1974

Effect of castration on pituitary and serum luteinizing hormone and follicle stimulating hormone in testosterone sterilized rats testosterone propionate metab. Neuroendocrinology 4(2): 101-111, 1969